A pioneer in clinical and experimental neuropathology, Price was a much loved faculty member and mentor. In the 1980s, his laboratory made seminal contributions to the understanding of Alzheimer's disease and amyotrophic lateral sclerosis, or ALS. In 1984, under Price's direction, the first donated brain was stored in the Johns Hopkins Hospital's pathology building. In 1971, Price was recruited to Johns Hopkins, where he founded the Division of Neuropathology. In 1984, he founded the Johns Hopkins Alzheimer's Disease Research Center, which he led for three decades.