Investigating respiratory disease using multiomics and advanced instrumentation

University of Technology Sydney
April 16, 2023
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Exceptional candidates with a background in analytical instrumentation, mass spectrometry, organic chemistry or similar are invited to apply for a fully funded scholarship under the supervision of Post-Doctoral fellow Dr Matthew O’Rourke at the UTS proteomics node and Prof Phil Hansbro at the Centre for inflammation, centenary institute.

Who is eligible?
  • Applicants must be either permanent Australian or New Zealand residents or citizens.
  • Applicants must hold a bachelor’s degree in a biomedical or biological science
  • Have a strong academic record and prior laboratory experience
  • Completion of Honours degree with First Class, or Second Class Division 1; or MSc Research; or MSc Coursework with a significant research component
  • Selection process

    Applicants must:

  • be highly motivated and capable of independent work
  • have a strong team focus
  • possess excellent communication skills and the ability to work with a diverse range of people and within established collaborative teams
  • have knowledge of a research/laboratory environment and requirements
  • be computer literate in standard research software
  • be able to maintain thorough laboratory records
  • possess experience with standard lab techniques such as biochemical extractions (proteins, lipids Metabolites), bacterial culture, reduction/alkylation procedures, accurate pipetting (~1ul), knowledge of sample normalization
  • be prepared to conduct in vivo mouse models and or collaborate with animal handling experts to run and coordinate in vivo animal models.
  • possess working knowledge of orbitrap mass spectrometry and imaging mass spectrometry
  • possess demonstrated experience in a biological mass spectrometry laboratory or similar.
  • Need more information? Contact...

    For more information please contact Dr. Matthew O'Rourke

    Other information

    In the field of respiratory disease, severe Asthma and Chronic Obstructive Pulmonary Disease (COPD) are the two greatest causes of morbidity resulting in severe breathing difficulties and illness, wheezing in asthma and often death in COPD. The recent COVID-19 pandemic has worsened the outcomes for patients with chronic respiratory disease. The result is an enormous ongoing cost both to individuals and health systems worldwide. The Center For Inflammation UTS / Centenary institute, led by Prof Hansbro has an internationally renowned track record in the development of human representative animal models to study severe asthma and COPD and is one of 4 Australian research institutes capable of studying in-vivo COVID-19 infections. By combining these established models together with advanced mass spectrometry-based proteomics, bulk and single cell RNA sequencing.

    This project aims to leverage our new capabilities in mass spectrometry imaging and large scale multi omics screening to elucidate the molecular landscape of COPD and severe asthma. The successful candidate will gain experience in experimental design, advanced mass spectrometry and associated techniques culminating in the creation of a multi omics based thesis.


    $32,500 per year; additional funds ($7.5k) during the course of the PhD for travel and other PhD-related expenses.


    3.5 years.




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